https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Functional importance of PP2A regulatory subunit loss in breast cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31424 Wed 15 Dec 2021 16:08:54 AEDT ]]> Deletion of Cd151 reduces mammary tumorigenesis in the MMTV/PyMT mouse model https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16760 −/− PyMT mice compared to Cd151+/+ PyMT littermate controls, this result was only approaching significance (Log-rank test P-value =0.0536). Interestingly, Cd151 deletion resulted in significantly reduced numbers and size of primary tumors but did not appear to affect the number or size of metastases in the MMTV/PyMT mice. Intriguingly, no differences in the expression of markers of cell proliferation, apoptosis and blood vessel density was observed in the primary tumors. Conclusion: The findings from this study provide additional evidence that CD151 acts to enhance tumor formation initiated by a range of oncogenes and strongly support its relevance as a potential therapeutic target to delay breast cancer progression.]]> Wed 11 Apr 2018 10:43:04 AEST ]]> Placental deficiency of the (pro)renin receptor ((P)RR) reduces placental development and functional capacity. https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54479 Tue 27 Feb 2024 15:03:44 AEDT ]]> Phospho-heavy-labeled-spiketide FAIMS stepped-CV DDA (pHASED) provides real-time phosphoproteomics data to aid in cancer drug selection https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51137 Tue 22 Aug 2023 15:58:50 AEST ]]> Ppp2r2aKnockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55 alpha, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41978 Tue 16 Aug 2022 15:48:51 AEST ]]> Synergistic Targeting of DNA-PK and KIT Signaling Pathways in KIT Mutant Acute Myeloid Leukemia https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51198 Thu 24 Aug 2023 15:01:24 AEST ]]> Shwachman-Bodian-Diamond syndrome (SBDS) protein is a direct inhibitor of protein phosphatase 2A (PP2A) activity and overexpressed in acute myeloid leukaemia https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42359 Mon 22 Aug 2022 14:08:27 AEST ]]> The (pro)renin receptor and soluble (pro)renin receptor in choriocarcinoma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47906 Mon 06 Feb 2023 14:42:00 AEDT ]]> Dual isolation of primary neurons and oligodendrocytes from guinea pig frontal cortex https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54665 Fri 08 Mar 2024 10:57:23 AEDT ]]>